- A strategy for gene cloning that relies on the identification of closely linked markers to the target trait, and then uses chromosome walking to identify, isolate and characterize the gene(s) responsible for the trait. The strategy is particularly appropriate when the biochemical basis of the target trait is unclear, thus precluding the use of a candidate gene approach.
Glossary of Biotechnology for Food and Agriculture . 2015.
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positional cloning — positional cloning. См. позиционное картирование. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
Positional cloning — Cloning a gene based simply on knowing its position in the genome without any idea of the function of that gene. Because this is the reverse of how things have been traditionally done, it has also been called reverse genetics. * * * DNA cloning… … Medical dictionary
positional cloning — Identification of a gene based on its location in the genome. Typically, this will result from linkage analysis based on a mutation in the target gene, followed by a chromosome walk from the nearest known sequence … Dictionary of molecular biology
Cloning — For the cloning of human beings, see Human cloning. For other uses, see Cloning (disambiguation). The sea anemone, Anthopleura elegantissima in process of cloning Cloning in biology is the process of producing similar populations of … Wikipedia
Cloning — The process of making a clone, a genetically identical copy. Cloning can refer to the technique of producing a genetically identical copy of an organism by replacing the nucleus of an unfertilized ovum with the nucleus of a body cell from the… … Medical dictionary
Functional cloning — involves using a known gene sequence as a probe to look for new gene sequences that may have similar functions, based on the similarity of sequence. Using this method of analysis, researchers can search through entire genomes to find genes of… … Wikipedia
позиционное картирование — positional cloning позиционное картирование. Начальный этап определения гена, мутация в котором обусловливает анализируемое НЗЧ; состоит в определении положения (картировании) локуса, генетически ассоциированного с этим заболеванием, на следующем … Молекулярная биология и генетика. Толковый словарь.
Genetic screen — This article is about a method to identify the functions of genes. For screening or testing for genetic diseases, see genetic testing. A genetic screen (often known as a phenotypic screen, or shortened to screen) is a procedure or test to… … Wikipedia
Francis Collins (geneticist) — Infobox Scientist name = Francis S. Collins imagesize = caption = Francis Collins at the National Human Genome Research Institute birth date = birth date and age|1950|4|14|mf=y birth place = Staunton, Virginia, United States alma mater =… … Wikipedia
Bruce A. Beutler — Bruce A. Beutler, an immunologist and geneticist, was born in Chicago, Illinois on 29 December, 1957, and is a US citizen. He is a Professor and Chairman of the Department of Genetics at The Scripps Research Institute, in La Jolla, California,… … Wikipedia