zinc finger

A DNA-binding protein motif, characterized by two closely spaced cysteine and two histidine residues that serve as ligands for a single Zn2+ ion. When bound, the structure takes on a conformation in which amino acid side chains protrude in a way that allows interaction with the DNA major groove.

Glossary of Biotechnology for Food and Agriculture . 2015.

Look at other dictionaries:

  • zinc finger — n any of a class of proteins that typically possess tandem repeats of fingerlike loops of amino acids with each loop containing a zinc binding site at its base consisting of two molecules of cysteine and two molecules of histidine and that… …   Medical dictionary

  • zinc finger —  Zinc Finger  Цинковый палец   Одна из основных групп белков, связывающих ДНК. Являются регуляторами транскрипции, содержат характерный домен, который включает 2 цистеиновых и 2 гистидиновых остатков. Эти аминокислоты взаимодействуют с ионом… …   Толковый англо-русский словарь по нанотехнологии. - М.

  • Zinc finger — A zinc finger is a large superfamily of protein domains that can bind to DNA. A zinc finger consists of two antiparallel beta; strands, and an α helix. The zinc ion is crucial for the stability of this domain type in the absence of the metal ion… …   Wikipedia

  • zinc finger — A motif associated with DNA binding proteins. A loop of 12 amino acids contains either 2 cysteine and 2 histidine groups (a cysteine histidine zinc finger), or 4 cysteines (a cysteine cysteine zinc finger), that directly coordinate a zinc atom.… …   Dictionary of molecular biology

  • zinc finger — noun : any of a class of proteins that typically possess tandem repeats of fingerlike loops of amino acids with each loop containing a zinc binding site at its base consisting of two molecules of cysteine and two molecules of histidine and that… …   Useful english dictionary

  • zinc finger — noun A structure, in some proteins, that binds to specific sequences of DNA and regulates genes …   Wiktionary

  • Zinc finger nuclease — Zinc finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA binding domain to a DNA cleavage domain. Zinc finger domains can be engineered to target desired DNA sequences and this enables zinc finger… …   Wikipedia

  • Zinc finger chimera — Zinc finger protein chimera are chimeric proteins composed of a DNA binding zinc finger protein domain and another domain through which the protein exerts its effect. The effector domain may be a transcriptional activator (A) or repressor… …   Wikipedia

  • Zinc finger and BTB domain-containing protein 16 — Zinc finger and BTB domain containing 16, also known as ZBTB16, is a human gene. PBB Summary section title = summary text = This gene is a member of the Krueppel C2H2 type zinc finger protein family and encodes a zinc finger transcription factor… …   Wikipedia

  • Zinc finger protein transcription factor — Zinc finger protein transcription factors or ZFP TFs, consisting of activators and repressors are transcription factors composed of a zinc finger protein domain (ZFP) and any of a variety of transcription factor effector domains which exert their …   Wikipedia

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